Combination Prevention: New Hope for Stopping the Epidemic
Identifieur interne : 002A08 ( Main/Exploration ); précédent : 002A07; suivant : 002A09Combination Prevention: New Hope for Stopping the Epidemic
Auteurs : Sten H. Vermund [États-Unis] ; Richard J. HayesSource :
- Current HIV/AIDS Reports [ 1548-3568 ] ; 2013.
Descripteurs français
- KwdFr :
- Acceptation des soins par le patient, Accessibilité des services de santé (), Afrique subsaharienne (épidémiologie), Agents antiVIH (usage thérapeutique), Complications de la grossesse et maladies infectieuses (), Complications de la grossesse et maladies infectieuses (épidémiologie), Comportement de réduction des risques, Comportement sexuel (), Connaissances, attitudes et pratiques en santé, Dépistage systématique, Facteurs socioéconomiques, Femelle, Grossesse, Humains, Infections à VIH (), Infections à VIH (épidémiologie), Mâle, Organisation mondiale de la santé, Politique de santé, Stigmate social, Transmission verticale de maladie infectieuse (), Travailleurs du sexe.
- MESH :
- usage thérapeutique : Agents antiVIH.
- épidémiologie : Afrique subsaharienne, Complications de la grossesse et maladies infectieuses, Infections à VIH.
- Acceptation des soins par le patient, Accessibilité des services de santé, Complications de la grossesse et maladies infectieuses, Comportement de réduction des risques, Comportement sexuel, Connaissances, attitudes et pratiques en santé, Dépistage systématique, Facteurs socioéconomiques, Femelle, Grossesse, Humains, Infections à VIH, Mâle, Organisation mondiale de la santé, Politique de santé, Stigmate social, Transmission verticale de maladie infectieuse, Travailleurs du sexe.
English descriptors
- KwdEn :
- Africa South of the Sahara (epidemiology), Anti-HIV Agents (therapeutic use), Female, HIV Infections (epidemiology), HIV Infections (prevention & control), Health Knowledge, Attitudes, Practice, Health Policy, Health Services Accessibility (statistics & numerical data), Humans, Infectious Disease Transmission, Vertical (prevention & control), Infectious Disease Transmission, Vertical (statistics & numerical data), Male, Mass Screening, Patient Acceptance of Health Care, Pregnancy, Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (prevention & control), Risk Reduction Behavior, Sex Workers, Sexual Behavior (statistics & numerical data), Social Stigma, Socioeconomic Factors, World Health Organization.
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- geographic , epidemiology : Africa South of the Sahara.
- epidemiology : HIV Infections, Pregnancy Complications, Infectious.
- prevention & control : HIV Infections, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious.
- statistics & numerical data : Health Services Accessibility, Infectious Disease Transmission, Vertical, Sexual Behavior.
- Female, Health Knowledge, Attitudes, Practice, Health Policy, Humans, Male, Mass Screening, Patient Acceptance of Health Care, Pregnancy, Risk Reduction Behavior, Sex Workers, Social Stigma, Socioeconomic Factors, World Health Organization.
Abstract
HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal microbicides, voluntary medical male circumcision, antiretroviral therapy (ART) for prevention (including prevention of mother to child HIV transmission [PMTCT]), treatment of sexually transmitted infections, use of clean needles for all injections, blood screening prior to donation, a future HIV prime/boost vaccine, and the female condom. The extent to which evidence-based modalities can be combined to prevent substantial HIV transmission is largely unknown, but combination approaches that are truly implementable in field conditions are likely to be far more effective than single interventions alone. Analogous to PMTCT, “treatment as prevention” for adult-to-adult transmission reduction includes expanded HIV testing, linkage to care, antiretroviral coverage, retention in care, adherence to therapy, and management of key co-morbidities such as depression and substance use. With successful viral suppression, persons with HIV are far less infectious to others, as we see in the fields of sexually transmitted infection control and mycobacterial disease control (tuberculosis and leprosy). Combination approaches are complex, may involve high program costs, and require substantial global commitments. We present a rationale for such investments and cite an ongoing research agenda that seeks to determine how feasible and cost-effective a combination prevention approach would be in a variety of epidemic contexts, notably that in a sub-Saharan Africa.
Url:
DOI: 10.1007/s11904-013-0155-y
PubMed: 23456730
PubMed Central: 3642362
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A11
- to stream Pmc, to step Curation: 000A10
- to stream Pmc, to step Checkpoint: 001A56
- to stream PubMed, to step Corpus: 001663
- to stream PubMed, to step Curation: 001663
- to stream PubMed, to step Checkpoint: 001663
- to stream Ncbi, to step Merge: 001D22
- to stream Ncbi, to step Curation: 001D22
- to stream Ncbi, to step Checkpoint: 001D22
- to stream Main, to step Merge: 002A19
- to stream Main, to step Curation: 002A08
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combination Prevention: New Hope for Stopping the Epidemic</title><author><name sortKey="Vermund, Sten H" sort="Vermund, Sten H" uniqKey="Vermund S" first="Sten H." last="Vermund">Sten H. Vermund</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Vanderbilt Institute for Global Health and Department of Pediatrics, Vanderbilt School of Medicine, 2525 West End Ave, Suite 750, Nashville, TN 37203 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt Institute for Global Health and Department of Pediatrics, Vanderbilt School of Medicine, 2525 West End Ave, Suite 750, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J." last="Hayes">Richard J. Hayes</name><affiliation><nlm:aff id="Aff2">MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT UK</nlm:aff><wicri:noCountry code="subfield">WC1E 7HT UK</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23456730</idno><idno type="pmc">3642362</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642362</idno><idno type="RBID">PMC:3642362</idno><idno type="doi">10.1007/s11904-013-0155-y</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000A11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A11</idno><idno type="wicri:Area/Pmc/Curation">000A10</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A10</idno><idno type="wicri:Area/Pmc/Checkpoint">001A56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A56</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001663</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001663</idno><idno type="wicri:Area/PubMed/Curation">001663</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001663</idno><idno type="wicri:Area/PubMed/Checkpoint">001663</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001663</idno><idno type="wicri:Area/Ncbi/Merge">001D22</idno><idno type="wicri:Area/Ncbi/Curation">001D22</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D22</idno><idno type="wicri:doubleKey">1548-3568:2013:Vermund S:combination:prevention:new</idno><idno type="wicri:Area/Main/Merge">002A19</idno><idno type="wicri:Area/Main/Curation">002A08</idno><idno type="wicri:Area/Main/Exploration">002A08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Combination Prevention: New Hope for Stopping the Epidemic</title><author><name sortKey="Vermund, Sten H" sort="Vermund, Sten H" uniqKey="Vermund S" first="Sten H." last="Vermund">Sten H. Vermund</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Vanderbilt Institute for Global Health and Department of Pediatrics, Vanderbilt School of Medicine, 2525 West End Ave, Suite 750, Nashville, TN 37203 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt Institute for Global Health and Department of Pediatrics, Vanderbilt School of Medicine, 2525 West End Ave, Suite 750, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J." last="Hayes">Richard J. Hayes</name><affiliation><nlm:aff id="Aff2">MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT UK</nlm:aff><wicri:noCountry code="subfield">WC1E 7HT UK</wicri:noCountry></affiliation></author></analytic><series><title level="j">Current HIV/AIDS Reports</title><idno type="ISSN">1548-3568</idno><idno type="eISSN">1548-3576</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa South of the Sahara (epidemiology)</term><term>Anti-HIV Agents (therapeutic use)</term><term>Female</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (prevention & control)</term><term>Health Knowledge, Attitudes, Practice</term><term>Health Policy</term><term>Health Services Accessibility (statistics & numerical data)</term><term>Humans</term><term>Infectious Disease Transmission, Vertical (prevention & control)</term><term>Infectious Disease Transmission, Vertical (statistics & numerical data)</term><term>Male</term><term>Mass Screening</term><term>Patient Acceptance of Health Care</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Pregnancy Complications, Infectious (prevention & control)</term><term>Risk Reduction Behavior</term><term>Sex Workers</term><term>Sexual Behavior (statistics & numerical data)</term><term>Social Stigma</term><term>Socioeconomic Factors</term><term>World Health Organization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acceptation des soins par le patient</term><term>Accessibilité des services de santé ()</term><term>Afrique subsaharienne (épidémiologie)</term><term>Agents antiVIH (usage thérapeutique)</term><term>Complications de la grossesse et maladies infectieuses ()</term><term>Complications de la grossesse et maladies infectieuses (épidémiologie)</term><term>Comportement de réduction des risques</term><term>Comportement sexuel ()</term><term>Connaissances, attitudes et pratiques en santé</term><term>Dépistage systématique</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (épidémiologie)</term><term>Mâle</term><term>Organisation mondiale de la santé</term><term>Politique de santé</term><term>Stigmate social</term><term>Transmission verticale de maladie infectieuse ()</term><term>Travailleurs du sexe</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa South of the Sahara</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term><term>Infectious Disease Transmission, Vertical</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Health Services Accessibility</term><term>Infectious Disease Transmission, Vertical</term><term>Sexual Behavior</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Afrique subsaharienne</term><term>Complications de la grossesse et maladies infectieuses</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Health Knowledge, Attitudes, Practice</term><term>Health Policy</term><term>Humans</term><term>Male</term><term>Mass Screening</term><term>Patient Acceptance of Health Care</term><term>Pregnancy</term><term>Risk Reduction Behavior</term><term>Sex Workers</term><term>Social Stigma</term><term>Socioeconomic Factors</term><term>World Health Organization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acceptation des soins par le patient</term><term>Accessibilité des services de santé</term><term>Complications de la grossesse et maladies infectieuses</term><term>Comportement de réduction des risques</term><term>Comportement sexuel</term><term>Connaissances, attitudes et pratiques en santé</term><term>Dépistage systématique</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Grossesse</term><term>Humains</term><term>Infections à VIH</term><term>Mâle</term><term>Organisation mondiale de la santé</term><term>Politique de santé</term><term>Stigmate social</term><term>Transmission verticale de maladie infectieuse</term><term>Travailleurs du sexe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>HIV research has identified approaches that can be combined to be more effective in transmission reduction than any 1 modality alone: delayed adolescent sexual debut, mutual monogamy or sexual partner reduction, correct and consistent condom use, pre-exposure prophylaxis with oral antiretroviral drugs or vaginal microbicides, voluntary medical male circumcision, antiretroviral therapy (ART) for prevention (including prevention of mother to child HIV transmission [PMTCT]), treatment of sexually transmitted infections, use of clean needles for all injections, blood screening prior to donation, a future HIV prime/boost vaccine, and the female condom. The extent to which evidence-based modalities can be combined to prevent substantial HIV transmission is largely unknown, but combination approaches that are truly implementable in field conditions are likely to be far more effective than single interventions alone. Analogous to PMTCT, “treatment as prevention” for adult-to-adult transmission reduction includes expanded HIV testing, linkage to care, antiretroviral coverage, retention in care, adherence to therapy, and management of key co-morbidities such as depression and substance use. With successful viral suppression, persons with HIV are far less infectious to others, as we see in the fields of sexually transmitted infection control and mycobacterial disease control (tuberculosis and leprosy). Combination approaches are complex, may involve high program costs, and require substantial global commitments. We present a rationale for such investments and cite an ongoing research agenda that seeks to determine how feasible and cost-effective a combination prevention approach would be in a variety of epidemic contexts, notably that in a sub-Saharan Africa.</p></div></front><back><div1 type="bibliography"><listBibl></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><noCountry><name sortKey="Hayes, Richard J" sort="Hayes, Richard J" uniqKey="Hayes R" first="Richard J." last="Hayes">Richard J. Hayes</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Vermund, Sten H" sort="Vermund, Sten H" uniqKey="Vermund S" first="Sten H." last="Vermund">Sten H. Vermund</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A08 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A08 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3642362
|texte= Combination Prevention: New Hope for Stopping the Epidemic
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23456730" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |